What is it about?
Serine hydromethyltransferase (SHMT) has a crucial role in the folate pathway. We have shown for the first time that this enzyme is a valid target to treat Malaria. A new class of highly potent inhibitors based on a pyrazolopyran scaffold is described.
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Why is it important?
Resistance against existing drugs to treat Malaria is a major concern to date. For this reason new valid target are urgently needed. Inhibition of SHMT is highly promising in that respect.
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This page is a summary of: Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities, Journal of Medicinal Chemistry, April 2015, American Chemical Society (ACS),
DOI: 10.1021/jm501987h.
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