What is it about?
Some evidence suggested that calcium uptake in dogs may be different to other species. Measuring as many metabolites as possible we wanted to identify any unforeseen effects in adult dogs fed diets differing in dietary Ca and found nothing of concern. We did, however, find that individual dogs seemed to have stable levels of metabolites over time and secondly, after a meal there are many, and varied, changes in metabolite levels, dependent on which metabolites one measures.
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Why is it important?
We set out to identify if dietary calcium fed at levels currently recommended were of any health concern to adult dogs by measuring as many metabolites as possible across a range of metabolic functions. We found no evidence to suggest a concern, supporting the conclusions of our previous, hypothesis-led work.
Perspectives
This was the first time we used metabolomics to complement a hypothesis-led study, the first post-prandial study we had done and also over the longest time (40 weeks). When the result is the "absence of an effect" it was wonderful to work with a group of experts willing to work in a collaborative way to see "what is influencing the metabolic profile"?
Dr David Allaway
Mars Inc
Read the Original
This page is a summary of: Metabolomic profiling to identify effects of dietary calcium reveal the influence of the individual and postprandial dynamics on the canine plasma metabolome, Journal of Nutritional Science, January 2019, Cambridge University Press,
DOI: 10.1017/jns.2019.12.
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