What is it about?
Management and Outcomes in the Oldest-Old Population with Glioblastoma. Glioblastoma is a lethal disease in the elderly population. We aimed to evaluate disease and treatment outcomes in the oldest-old patients. Methods: Patients >80 years old with histologically confirmed glioblastoma treated between 2004 and 2009 were identified. We included patients managed with best supportive care (BSC), temozolomide (TMZ) alone, radiotherapy (RT) alone, or concomitantly with TMZ (CRT). Survival outcomes were analyzed.
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Why is it important?
Glioblastoma is a lethal disease in the elderly population.
Perspectives
Conclusions: PFS and OS outcomes remain poor in the oldest-old patients (>80 years old). Younger age, lower AAC, surgical resection, and adjuvant treatment were associated with improved Overall survival. The results of this study impacted clinical practice, determining that the "Oldest-Old Population with Glioblastoma" is a particular subtype of patients needing a targeted management.
Dr Catherine Maurice
University of Toronto
Read the Original
This page is a summary of: Management and Outcomes in the Oldest-Old Population with Glioblastoma, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, December 2017, Cambridge University Press,
DOI: 10.1017/cjn.2017.278.
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