What is it about?
In this review, we analyse the expression of CD28 co-stimulatory molecules andNK-Rs in several situations that involve chronic activation of the immune system,including in vivo and in vitro studies.
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Why is it important?
It has been demonstrated that at birth almost all human peripheral blood CD8+ T cells areCD28+, and that the proportion of CD8+CD28-T cells increase with age.
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This page is a summary of: CD28 downregulation and expression of NK-associated receptors on T cells in aging and situations of chronic activation of the immune system, January 2002, Elsevier,
DOI: 10.1016/s1566-3124(02)13007-0.
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