What is it about?
ocular surface stress, for example, in the form of hyperosmolar tears, stimulate the activation of mitogen activated protein kinases. Activation of these pathways induce formation of proinflammatory cytokines and chemokines, which propagate the inflammation in dry eye
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Why is it important?
kinase inhibitors may have a role in treatment of dry eye
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This page is a summary of: Stress-activated Protein Kinase Signaling Pathways in Dry Eye and Ocular Surface Disease, The Ocular Surface, October 2005, Elsevier,
DOI: 10.1016/s1542-0124(12)70244-6.
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