Reduced inflammation and improved airway expression using Helper-Dependent adenoviral vectors with a k18 promoter

What is it about?

Cystic fibrosis is a severe genetic disease that causes severe damage to the respiratory and digestive systems. Lung gene therapy to treat cystic fibrosis might be achieved by delivering a correct copy of the CFTR (Cystic Fibrosis Transmembrane conductance Regulator) gene to airway epithelial cells. In the current manuscript authors describe an innovative gene therapy approach for efficient, long-lasting transduction of airway epithelial cells with negligible acute toxicity. This new vector could be a significant development towards eventual lung gene therapy for cystic fibrosis.

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Photo by Robina Weermeijer on Unsplash

Photo by Robina Weermeijer on Unsplash