What is it about?
Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi. Hydroperoxide metabolism in T. cruzi been shown to be catalyzed by a cascade of three oxidoreductases comprising trypanothione reductase, tryparedoxin, and tryparedoxin peroxidase. The antioxidant defense of T. cruzi also depends on the NADPH-fuelled, trypanothione-mediated enzymatic hydroperoxide metabolism.
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Why is it important?
The oxidant defense system of the trypanosomatids has therefore been considered as the Achilles heel of these important pathogens.
Perspectives
Chagas disease treatment
Dr. Jorge A. López
Read the Original
This page is a summary of: Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi, Free Radical Biology and Medicine, March 2000, Elsevier,
DOI: 10.1016/s0891-5849(00)00159-3.
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