IP injection of extracellular vesicles from heart-derived cells is safe after myocardial infarction

What is it about?

Available data suggest that the use of extracellular vesicles (EV) recapitulates the effects seen using their cells of origin. The aim of this study was to assess the effects of EV obtained from heart-derived cells administered into the pericardium early after experimental miocardial infarction in pigs.

Featured Image

Why is it important?

No significant differences between groups were found in MR-derived cardiac function parameters at 10 weeks, despite a trend towards improved cardiac function in treated animals. Masson's trichrome staining showed no evident anatomopathological differences between groups in either remote, infarct or border zone.