Safety and efficacy assessment of intracoronary delivery of porcine cardiac stem cells

What is it about?

The main objective of this study was to evaluate in a swine acute myocardial infarction model the safety and efficacy of an intracoronary injection of two different doses of allogeneic porcine cardiac stem cells (pCSCs).

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Why is it important?

A slight increase in Tpn I was observed after cell/vehicle delivery without significant differences between groups. Higher EF and lower EDV and ESV values were found in the pCSC-treated animals compared to controls (table). The histological study revealed a greater extension of fibrosis in the control pigs.