The intrapericardial delivery, an efficient method for pharmacological agent delivery

What is it about?

The administration routes should ensure the viability, proliferative potential, homing capacity and implantation of transferred cells. The intrapericardial delivery has been defined as an efficient method for pharmacological agent delivery. It has a low turnover rate and provides a long term effect to achieve the desired therapeutic effect.

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Why is it important?

The pericardial fluid could be considered an optimal vehicle for MSCs delivery maintaining their viability and their retention. Moreover, the inflammatory environment observed in the pericardial fluid from infarcted hearts may trigger the release of immunomodulatory factors from MSCs.