What is it about?
Different aspects of the immune response are severely affected by age. Thus, we have studied the effect of aging on NKT cells from healthy elderly individuals
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Why is it important?
Our results demonstrated a decreased percentage of CD3+Valpha24+ cells in peripheral blood from elderly donors, whereas mainstream T lymphocytes showed an age-associated decrease in the expression of CD28, the vast majority of CD3+Valpha24+ cells from old individuals were CD28+. A significant increase in the percentage of Valpha24+ cells with the CD4-CD8+ phenotype was also found in the elderly, indicating a redist
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This page is a summary of: Vα24+ NKT cells are decreased in elderly humans, Experimental Gerontology, January 2002, Elsevier,
DOI: 10.1016/s0531-5565(01)00186-3.
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