What is it about?
Shows that for analysing trials with many small centres conventional meta-analysis is a bad idea
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Why is it important?
Because estimated variances can vary randomly, weighting centres by observed precision is inefficient and will lead to significance tests that are too liberal. A linear model approach is preferable.
Read the Original
This page is a summary of: Letter to the editor, Controlled Clinical Trials, December 2000, Elsevier,
DOI: 10.1016/s0197-2456(00)00105-7.
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