What is it about?
Buccal dosage form for nitroglycerin and isosorbide dinitrate. This dosage form is prepared from a thin tablet which is covered by a mucoadhesive film and a film having a hole where the tablet disintegrates and releases the active agents gradually.
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Why is it important?
Application of this bauccal tablet to the buccal mucosa of beagle dogs showed prolonged time of blood nitroglycerin with bioavailability increase (avoidance of first pass effect).
Perspectives
This buccal dosage form is very simple and applicable to any drugs (ex. morphine and fentanyl). The applications to some durgs exhibiting large first-pass efeect are demonstrated in the book (Modified-release drug delivery technology, Mracel Dekker).
Dr Katsumi Iga
Doshisha Joshi Daigaku
Read the Original
This page is a summary of: Sustained-release buccal dosage forms for nitroglycerin and isosorbide dinitrate: increased bioavailability and extended time of absorption when administered to dogs, Journal of Controlled Release, December 1997, Elsevier,
DOI: 10.1016/s0168-3659(97)00079-5.
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