Reductions stereoselectives d'acetyl β-lactames

Featured Image

Why is it important?

Trans acetyl betalactam were stereoselectively reduced by different reagents to afford the correspondzng trans erythro and/or trans threo alcohols in high stereoselectivity ofr the first time. The trans erythro configuraton as found in thienamycin antibiotic was attained through K-selectride mediated reduction (65/1) or catalytic hydrogenation over PtO2 (34/1) while the threo one was obtained under Li Selctride reduction (6.3/1). Relative configurations were determined by chemical correlation.