Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies

What is it about?

The MDRD formula seems to be more accurate than the Cockcroft–Gault formula for dosing carboplatin in patients with gynecological cancers, although both have limited precision. The MDRD formula is a reasonable alternative to the Cockcroft–Gault formula dosing carboplatin in patients with gynecological cancers.

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Why is it important?

The MDRD formula is used to provide estimated GFR based on serum cretinine reported by laboratories. Therefore, it can potentially reduce human errors in calculating creatinine clearance based on the Cockcroft–Gault formula, serum creatinine and body weight.