Xenopus in vivo imaging of inflammation

What is it about?

In the manuscript we investigated the inflammatory response following various sterile and infected wound assays. By using single and double transgenic lines, we were able to perform time-lapse fluorescence imaging on various innate immune cells following injury and infection. We monitored the morphology and migratory behaviour of various inflammatory cells, including granulocytes and macrophages, and we concluded that the inflammatory response in Xenopus larvae during wound healing is very similar to that found in humans. Thus Xenopus larvae provide an easily tractable system to investigate the inflammatory response to injury in a living organism, which is relevant to humans.

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