What is it about?
We have developed a novel intra-vital semi-solid tumor model in transparent tadpoles, which recapitulates many of the functional characteristics of mammalian tumorigenesis.
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Why is it important?
The availability of a reliable comparative model that is cost-effective and easily accessible to manipulation should reveal useful for the development of new drugs targeting angiogenesis and extracellular matrix or promoting antitumor immunity.
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This page is a summary of: Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration, Developmental Biology, December 2015, Elsevier,
DOI: 10.1016/j.ydbio.2015.01.003.
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