What is it about?
We repurposed the antimalarial pyronaridine as an anti tubercular as it showed synergy with Rifampicin in vitro.
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Why is it important?
We proposed that pyronaridine may target the same protein as Rifampicin in Mtb, namely RNA polymerase. We present various data to show pyronaridine also has activity on its own but is markedly more active alongside Rifampicin.
Perspectives
This article was a very large collaborative effort taking several years and itself extending outside of the MM4TB project where it originated.
Dr Sean Ekins
Collaborations in Chemistry
Read the Original
This page is a summary of: The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase, Tuberculosis, September 2018, Elsevier,
DOI: 10.1016/j.tube.2018.08.004.
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