Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors

What is it about?

Present common pitfalls of gene delivery vectors when transitioning from 1) in vitro and 2) preclinical models and paradigm shifts required to traverse these barriers.

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Why is it important?

With each passing year, scientists present various technological strategies designed to overcome specific administration or processing barriers associated with delivery of genetic material. Despite this technological renaissance, only a marginal amount of these strategies are capable of successfully traversing the transition from bench to clinic. Accordingly, translational failure can be attributed to paradigms and methodologies used to design and assess each particular strategy. Thus, with the use of contemporary characterization and physiological-mimicry tools, scientist are now capable of deciphering the intricate interplay of synthetic and biological mechanisms acting at different scales — from the subcellular to the macroscopic — endowing the ability to design and test strategies that will have improved translational capabilities.