What is it about?
Antidepressant-like activity,
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Why is it important?
The MP extract (200 and 400 mg/kg, i.p.) showed a significant antidepressant-like effect (P < 0.001), in the FST, but it did not change the spontaneous locomotor activities in the open-field test. Pretreatment of animals with SCH23390, sulpiride, haloperidol, prazosin, yohimbine, WAY100135, ketanserin, and p-chlorophenyla- lanine (pCPA) reversed the antidepressant-like effect of the MP extract (400 mg/kg, i.p.) in the FST. In addition, the administration of reserpine increased the duration of immobility elicited by the MP extract in animals. Combinations of the MP extract (50 mg/kg, i.p.,) with sub-effective doses of fluoxetine (5 mg/ kg, i.p.) or imipramine (5 mg/kg, i.p.) potentiated the antidepressant-like response. The ethanolic extract of MP exerts antidepressant-like effects, which might be mediated through dopaminergic (D1 and D2), noradrenergic (a1 and a2), and serotonergic (5-HT1A, 5-HT2A) receptors. These first results including the potentiating effect of the MP extract on fluoxetine and imipramine suggest further investigations of MP for the management of depression.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long-standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.
Dr Saeid Abbasi-Maleki
Islamic Azad University
Read the Original
This page is a summary of: Involvement of the monoaminergic system in the antidepressant-like effect of the crude extract of Mentha piperita (Lamiaceae) in the forced swimming test in mice, Synergy, December 2017, Elsevier,
DOI: 10.1016/j.synres.2017.08.002.
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