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Using a correlative 3D live-cell and cryoET method, we showed under near-native conditions that intact hyperstable mutant HIV-1 cores are present in the cytoplasm of host cells. We further obtained direct evidence to suggest that a hyperstable mutant capsid, E45A, showed delayed capsid disassembly compared to the wild-type capsid.

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This page is a summary of: Direct Visualization of HIV-1 with Correlative Live-Cell Microscopy and Cryo-Electron Tomography, Structure, November 2011, Elsevier,
DOI: 10.1016/j.str.2011.09.006.
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