What is it about?
The ideal goal of treatment for juvenile idiopathic arthritis (JIA) is disease remission. However, many sets of remission criteria have been developed and no systematic review of remission in JIA exists. This research investigated (1) how remission has been defined across JIA clinical cohorts and (2) the frequency of remission overall and within disease categories.
Featured Image
Why is it important?
Within 17 studies reviewed, 13 sets of criteria for clinically inactive disease and remission were identified. The frequency that remission was reported increased with longer disease duration from 7% within 1.5 years to 47% by 10 years following diagnosis. Patients with persistent oligoarticular were more likely to achieve remission, and patients with rheumatoid-factor positive polyarticular JIA were least likely to achieve remission. Many patients remain in active disease, even in contemporary cohorts. The multiple sets of outcome criteria meant we were unable to compare between studies.
Perspectives
My main role in this analysis was as the second independent reviewer of study titles and abstracts. I enjoyed working with first author Shoop-Worrall and look forward to any future collaborations we may get the opportunity to have.
Dr. Lianne Kearsley-Fleet
University of Manchester
Read the Original
This page is a summary of: How common is remission in juvenile idiopathic arthritis: A systematic review, Seminars in Arthritis and Rheumatism, December 2017, Elsevier,
DOI: 10.1016/j.semarthrit.2017.05.007.
You can read the full text:
Resources
Contributors
The following have contributed to this page
