What is it about?
The inhibition of the proteolytic activity of Haemonchus contortus lysate by a mixture of n-alkyl ferulates isolated from Maprounea guianensis. These compounds were evaluated in vitro for the ability to inhibit the parasite proteases using zymography
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Why is it important?
The ferulates abrogated the proteolysis compared to E-64, suggesting the activity is the result of a cysteine protease
Perspectives
ferulates may be a potential drug for hemonchosis treatment. However, further studies are required to evaluate the potential therapeutic uses of ferulates.
Dr. Jorge A. López
Read the Original
This page is a summary of: Haemonchus contortus protease inhibition by n-alkyl ferulates from Maprounea guianensis, Research in Veterinary Science, June 2012, Elsevier,
DOI: 10.1016/j.rvsc.2011.06.001.
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