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Valproic acid is a leading antiepileptic drug widely prescribed from children to elderly. In order to increase its efficacy and to reduce its side effects, derivatives based on oligo-metals and ligands are developped. In this article, the toxicity of complexes were assayed against a brine schrimp, as a model of living organism. As expected, complexes based on zinc are less toxic to this schrimp than the one based on copper. Data have to be completed by relevant toxicological assays.
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This page is a summary of: Synthesis, structural characterization and previous cytotoxicity assay of Zn(II) complex containing 1,10-phenanthroline and 2,2′-bipyridine with valproic acid, Polyhedron, April 2015, Elsevier,
DOI: 10.1016/j.poly.2015.02.012.
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