What is it about?
Unlocking the Potential of Edible Seed Peptides: Could They be the Solution to COVID-19? Our study analyzes the anti-COVID-19 properties of peptides released from edible seeds during gastrointestinal digestion. Using in silico and molecular docking approaches, we examine 19 seed storage proteins and their potential to release multi-target anti-COVID-19 peptides. Our results reveal that 36 of the 1593 released peptides have high GI absorption capacity and binding affinity towards key proteins such as spike protein, main protease, and papain like protease of SARS CoV 2 virus. Join us in exploring this promising avenue for COVID-19 treatment.
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Why is it important?
• This study is important as it suggests that edible seeds could be a potential source of anti-COVID-19 peptides upon GI digestion, which can help in the treatment and management of COVID-19. • The findings from this research paper provide an alternative to existing treatments for SARS CoV 2 virus infection by using natural sources like edible seed proteins instead of synthetic drugs or phytochemicals.
Read the Original
This page is a summary of: SARS-CoV-2 spike protein-, main protease- and papain-like-protease-targeting peptides from seed proteins following gastrointestinal digestion: An in silico study, Phytomedicine Plus, February 2021, Elsevier,
DOI: 10.1016/j.phyplu.2020.100016.
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Resources
Figure 1
Binding poses of five top-score seed peptides on the surface of Mpro: (A) PW, (B) PSF, (C) IVF, (D) PGF, (E) PIL; on PLpro: (F) PW, (G) PSF, (H) PGF, (I) IVF, (J) PY; and on spike protein RBD: (K) PW, (L) PSF, (M) PGF, (N) APY, (O) IVF.
In Silico Identification of Multi-target Anti-SARS-CoV-2 Peptides from Quinoa Seed Proteins
•This study aimed to investigate the potential of peptides derived from quinoa seed proteins as multi-target antagonists against SARS-CoV-2, which is a virus that causes severe acute respiratory syndrome.
Identification of Putative Cell‐entry‐inhibitory Peptides against SARS‐CoV‐2 from Edible Insects: An in silico Study
... identify potential SARS-CoV-2 cell entry inhibitors from peptides derived from edible insects.
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