What is it about?
The current study explaining the underlying mechanism of chloroquine-induced itch which is dependent on MrgprA3 receptors. We showed that increased NO production by nNOS, participate in CQ-induced itch.
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Why is it important?
Our findings better clarify the role of NO in itch and its involvement in CQ-induced pruritic behavior in mice which is MrgprA3 dependent.
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This page is a summary of: Chloroquine-induced scratching is mediated by NO/cGMP pathway in mice, Pharmacology Biochemistry and Behavior, July 2015, Elsevier,
DOI: 10.1016/j.pbb.2015.04.016.
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