What is it about?
Edaravone is an anti-oxidant in acute iscemic brain disorders. We investigated the effects of edaravone on the production of nitric oxide and reactive oxiegen speecies and proinflammatory cytokines, produced by activated microglia. We also examined the neuroprotective role of edaravone in cortical neuronal cultures oxidatively stressed by the peroxynitrite or activated microglia.
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Why is it important?
Our findings show edaravone suppressed the production of NO and ROS by activated microglia, though it did not suppress production of inflammatory cytokines. Moreover, edaravone suppressed neuronal cell death and dendrotoxicity induced by either the peroxynitrite or activated microglia. Therefore, Edaravone may act as a neuroprotective agent counteracting oxidative neurotoxicity arising from activated microglia.
Perspectives
I hope this article provides possible mechanism how edaravone acts for patients with inflammatory or neurodegenerative disorders of the central nervous system.
Dr Masahiro Banno
Seichiryo Hospital
Read the Original
This page is a summary of: The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia, Neuropharmacology, February 2005, Elsevier,
DOI: 10.1016/j.neuropharm.2004.10.002.
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