What is it about?
A novel pyrrolizidine alkaloid was isolated and purified from the aerial parts of Crotalaria retusa L. Structural elucidation of the alkaloid was established by analyses of high field NMR spectra and quantum mechanical calculations.
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Why is it important?
Pyrrolizidine alkaloids (PAs) belong to a group of secondary metabolites, found in many plants. These PAs are present in more than 6000 plants. This leguminous is found in tropical and subtropical regions and it has been used as the basis of folk medicine.The potential use of these compounds in the treatment of diseases such as diabetes and cancer, or their application as nematicide, are driving forces to look for new natural PAs or new less cytotoxic synthetic derivative. Theoretical computation associated with spectroscopic data was used to establish the relative stereochemistry of this natural product.
Perspectives
The structure of a novel macrocyclic alkaloid was elucidated by NMR interpretation and theoretical calculations. The NMR spectra were interpreted in order to facilitate the follow-up by the reader. The theoretical calculations were performed and described in such a way that it can be reproduced by the reader.
Professor Elson Santiago Alvarenga
Universidade Federal de Vicosa
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This page is a summary of: Structural elucidation of a novel pyrrolizidine alkaloid isolated from Crotalaria retusa L., Journal of Molecular Structure, January 2022, Elsevier,
DOI: 10.1016/j.molstruc.2022.132394.
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