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The structural modification of natural products has shown to be a remarkable tool in the generation of novel bioactive molecules. Herein, the synthesis, structural analysis and anticancer activity of the novel triterpenoid thiazole 3 is reported. The cytotoxicity and antiproliferative activity of 1, the diastereomeric mixture of 2-bromo ochraceolide A (2a and 2b) and 3 against three cancer cell lines (MCF-7, MDA-MB-231 and SiHa) were investigated. The novel thiazole derivative 3 exhibited significant cytotoxicity and antiproliferative activity against the three cancer cells.
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This page is a summary of: Synthesis, structure analysis and activity against breast and cervix cancer cells of a triterpenoid thiazole derived from ochraceolide A, Journal of Molecular Structure, March 2020, Elsevier,
DOI: 10.1016/j.molstruc.2019.127555.
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