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The fission yeast FANCM-ortholog Fml1 has two roles in homologous recombination – it promotes gene conversion at stalled replication forks and limits crossing over during mitotic double-stranded DNA break repair. In vitro Fml1 catalyzes replication fork reversal and D-loop disruption, indicating potential mechanisms by which it fulfills pro- and antirecombinogenic roles.
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This page is a summary of: The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair, Molecular Cell, October 2008, Elsevier,
DOI: 10.1016/j.molcel.2008.08.024.
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