What is it about?
As an intracellular parasite, Trypanosoma cruzi is exposed to reactive oxygen species. The study of the proteins involved in the hydroperoxide detoxification cascade, tryparedoxin peroxidase included, may lead to the development of a more specific chemotherapy for Chagas'disease. The limited transcriptional regulation capacity requires the polycistronic unit transcription, which may explain the few promoter identification. Oxidative stress is increased exposure to oxidants or decreased activity of antioxidant mechanisms.
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Why is it important?
The importance of TcCPX on the parasite protection against fluctuating levels of ROS generated during physiological processes and validate this enzyme as a drug target for Chagas’ disease treatment.
Perspectives
Drug target for Chagas’ disease treatment.
Dr. Jorge A. López
Read the Original
This page is a summary of: Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide, Molecular and Biochemical Parasitology, January 2004, Elsevier,
DOI: 10.1016/j.molbiopara.2003.08.011.
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