Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-α and GPER signalling

What is it about?

Stress, poor dietary choices and chemical exposures interact with common male and female hormones....to increase fat deposition, overweight and obesity; breast tenderness, breast growth and breast cancer; period problems and womb cancer, prostate growth and prostate cancer; pre-diabetes and diabetes; and heart disease and stroke. Stress hormone, insulin, pesticides, skin and sun cream components, etc., all play a key role. This association has been suspected for ages...now discover the mechanism, and more importantly, the strategies required to reduce the incidence and cost of these diseases.

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Why is it important?

Obesity and overweight are growing faster than waistlines; breast cancer and prostate cancer are the most common cancers in women and men; diabetes is skyrocketing, and heart disease, our greater killer, increases relentlessly. You don't need to be Einstein to realise that they could all be related...a common-link. This paper simplifies the hormonal interactions at the root of this 21st century epidemic...a shift in medical thinking...a new awareness, that will see prevention, rather than treatment, gain acceptability in managing global health.