C. elegans screening strategies to identify pro-longevity interventions

What is it about?

Screening technologies are developing fast and the number of new synthetized chemicals increase everyday. We summarize in this review what are the possibilities to use the nematode Caenorhabditis elegans as a drug screening tool to identify new compounds extending healthy lifespan. In this context, we describe our recently developed screening strategy which takes advantage of the phenotypes observed in C. elegans upon different degrees of mitochondrial stress.

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Why is it important?

C. elegans Mit mutants provide quantifiable phenotypic readouts exploitable in high-throughput and high-content screenings. Precise readouts are critical to make the process of drug discovery fast and effective. Moreover, the research for pro-longevity drugs without actually perform longevity assays greatly facilitates and accelerates the process.