What is it about?
CD34+ hematopoietic stem/progenitor cells (HSPCs) express limited levels of human immunodeficiency virus (HIV) receptor (CD4) and resistant to HIV infection. In this study, we found an optimal in vitro condition in which HSPC can be infected by HIV.
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Why is it important?
Loss of bone marrow CD34+ cells and hematopoiesis potential in HIV+ patients may be critical in development of acquired immunodeficiency syndrome (AIDS), but the underlying mechanisms are still poorly understood. In addition, it has been difficult to analyze those cells in vitro in the presence of HIV.
Perspectives
By using the optimal condition for HIV infection of HSPCs in vitro, we hope researchers will be able to better analyze the impact of HIV on bone marrow functions, as well as to develop a method or treatment to preserve these functions.
Dr Tetsuo Tsukamoto
Read the Original
This page is a summary of: The use of RetroNectin in studies requiring in vitro HIV-1 infection of human hematopoietic stem/progenitor cells, Journal of Virological Methods, October 2017, Elsevier,
DOI: 10.1016/j.jviromet.2017.08.003.
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