What is it about?
We do repeated impression cytology to assay the level of transcripts in the conjunctiva at different time points after glaucoma surgery.
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Why is it important?
Inflammatory gene expression is significantly downregulated years after trabeculectomy (in six critical genes). This shows that glaucoma surgery may be preferable to long term chronic glaucoma medications that induce inflammation.
Perspectives
The timing of glaucoma surgery is an important issue in patients requiring multiple or chronic glaucoma eyedrops. These eyedrops need to be made safer, and for patients with poor ocular surface, earlier surgery may be warranted. There should be interdisciplinary joint management of these patients between glaucoma and ocular surface departments.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Altered expression level of inflammation-related genes and long-term changes in ocular surface after trabeculectomy, a prospective cohort study, The Ocular Surface, October 2018, Elsevier,
DOI: 10.1016/j.jtos.2018.06.005.
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