What is it about?
The article delves into techniques for loading therapeutic agents into exosomes, particularly those derived from human plasma. It may discuss both active (involving specific targeting mechanisms) and passive (based on natural uptake processes) approaches to loading drugs into these exosomes. The focus is on enhancing drug delivery efficiency and efficacy through exosome-based systems.
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Why is it important?
1. Targeted Drug Delivery: Exosomes have emerged as promising vehicles for drug delivery due to their natural ability to traverse biological barriers and target specific cells. 2. Biocompatibility: Being derived from human plasma, exosomes are generally well-tolerated by the body, reducing the risk of immunogenic reactions compared to synthetic nanoparticles. 3. Enhanced Pharmacokinetics: Loading drugs into exosomes can improve their stability,
Perspectives
From a broader perspective, the research holds significant implications for advancing personalized medicine and targeted therapies. By harnessing exosomes derived from human plasma, researchers can potentially overcome many challenges associated with traditional drug delivery methods. This approach may lead to more effective treatments for various diseases, including cancers, neurodegenerative disorders, and inflammatory conditions, where targeted and efficient drug delivery is critical
Dr Faisal Gulzar
University of Sargodha
Read the Original
This page is a summary of: Human plasma derived exosomes: Impact of active and passive drug loading approaches on drug delivery, Saudi Pharmaceutical Journal, June 2024, Elsevier,
DOI: 10.1016/j.jsps.2024.102096.
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