What is it about?
This study in young male soldiers aims to explore long-term outcomes of combat blast injuries, focusing on the relationship between osteoarthritis blood markers and knee osteoarthritis diagnosed through x-rays. One marker called COMP, which is present in cartilage, was higher in injured participants, and lower in those with amputations, showing the importance of healthy joints for producing COMP.
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Why is it important?
There were no molecular differences in those with OA in the injured group with (probable post traumatic OA) and those in the control non-injured (probably idiopathic OA) groups, suggesting a common mechanism at 8 years post injury as suggested by a previous study using UK BioBank data.
Read the Original
This page is a summary of: Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – findings from the ADVANCE study, Osteoarthritis and Cartilage, August 2024, Elsevier,
DOI: 10.1016/j.joca.2024.07.016.
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