What is it about?
The leaf extract from Prosthechea karwinskii was examined to identify its compounds and elucidate its inhibitory effect on reactive oxygen species as well as its anti-inflammatory activity and gastroprotective effects in Wistar rats.
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Why is it important?
Nine compounds were identified in the P. karwinskii leaf extract. Most compounds, such as quinic acid, malic acid, neochlorogenic acid, chlorogenic acid, rutin, embelin, pinellic acid, and azelaic acid, were reported to exhibit antioxidant and/or anti-inflammatory activity. The extract was also found to inhibit reactive oxygen species in the ex vivo model. Unlike other anti-inflammatory drugs, the extract exerted a dual effect: anti-in- flammatory activity and protection of the gastric mucosa. The results showed that the extract could significantly inhibit the release of nitric oxide without a dose-response relationship.
Perspectives
From this paper the bioactivity of Prosthechea karwinskii was found to support its use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing side effects associated with nonsteroidal anti-inflammatory drugs. The findings herein form the basis for the future discovery of natural products that may serve as safe alternative therapies for inflammatory disorders.
Rodolfo Solano
Instituto Politecnico Nacional
Read the Original
This page is a summary of: Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS, Journal of Ethnopharmacology, May 2020, Elsevier,
DOI: 10.1016/j.jep.2020.112632.
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