What is it about?
The present investigation was intended to formulate and evaluate a hot-melt extruded (HME) bioadhesive ophthalmic inserts containing a fixed-dose combination of Prednisolone Sodium Phosphate (PSP) and Sulfacetamide Sodium (SA) to improve the treatment outcomes of multiple ocular bacterial infections. The inserts were prepared using FDA-authorised biocompatible polymers, including Polyox WSR N10 LEO NF (polyethylene oxide), Klucel™ HF (hydroxypropyl cellulose), and Ethocel™.
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Why is it important?
The ocular inserts were fabricated using a solvent-free, scalable, and continuous manufacturing process and could reduce the frequency of administration to once-daily application, affording a new topical delivery vehicle with prolonged antibacterial and anti-inflammatory activity during ocular bacterial infections treatment.
Perspectives
This article is mainly about the dual drug-loaded Ocular inserts of Sulfacetamide and Prednisolone prepared by solvent-free and continuous manufacturing HME process.
Dr Sateesh Kumar Vemula
University of Mississippi
Read the Original
This page is a summary of: Formulation development and characterization of dual drug loaded hot-melt extruded inserts for better ocular therapeutic outcomes: Sulfacetamide/prednisolone, Journal of Drug Delivery Science and Technology, June 2023, Elsevier,
DOI: 10.1016/j.jddst.2023.104558.
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