What is it about?
Resveratrol is a natural product that can be extracted from plants, has cancer-treating and -preventing capabilities. It is also used as skin bleaching, weight losing and age-related diseases such as Alzheimer disease. The major problem of this natural product is its low water solubility and decreased absorption. Therefore, many nano-carriers were developed to overcome this setback. After loading this compound on diverse kinds of nano-formulations, it was feasible to be used orally, topically, and parenterally.
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Why is it important?
It shed more light on natural compounds that have many medical uses but can't be exploited correctly due to low absorption issues. Resveratrol in nano-carriers and in combination with other anti-cancer agents, genes and phytochemicals can be used as anti-cancer formulation with less resistance problem such as the traditional agents.
Perspectives
Firstly, when resveratrol combined with genes that are considered as cancer cells killers, it was activated inside cancer cells and expressed more proteins, and suppressed tumor cells in a higher rate compared to other preparations without resveratrol. Secondly, the emergence of dual encapsulation techniques is considered a new trend in medicines and phytochemicals encapsulation that can reduce the toxicity of some nanocarriers to the human body. Thirdly, introducing the green technology in noncarriers for targeting diseases is considered an important future perspective towards giving positive impacts on environmental and economic sustainability.
Dr. Said Moshawih
Universiti Brunei Darussalam
Read the Original
This page is a summary of: Potential application of resveratrol in nanocarriers against cancer: Overview and future trends, Journal of Drug Delivery Science and Technology, October 2019, Elsevier,
DOI: 10.1016/j.jddst.2019.101187.
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