What is it about?
While “age” is one of the most powerful risk factors for cardiovascular disease, the mechanisms of adaptation that alter the cardiovascular system during “normal’ human adult life remain largely unknown. Fundamental questions such as what are the aging changes in left ventricular remodeling and function in the normal adult’s life, and is why some individuals age with their left ventricular systolic function relatively intact whereas in others myocardial function declines leading to heart failure remain unanswered.
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Why is it important?
The study demonstrates that, increased LV mass (g), male sex, increased blood pressure, increased heart rate, and reduced HDL-C were associated with reduced heart function, but continued use of antihypertensive medication maintained or improved heart fucntion.
Perspectives
Wringing morion of heart (torsion) may be a key to compensation mechanisms against alterations of cardiovascular systems by aging. Although prospective and observational as opposed to controlled by randomization, our study adds to the current knowledge about the potential benefits of antihypertensive therapy for longer periods of time.
Dr Kihei Yoneyama
St. Mariannna University School of Medicine
Read the Original
This page is a summary of: Natural History of Myocardial Function in an Adult Human Population, JACC Cardiovascular Imaging, October 2016, Elsevier,
DOI: 10.1016/j.jcmg.2016.01.038.
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