(CCTTT)n repeat polymorphism in NOS2 promoter influenced asthma exacerbation

What is it about?

Polymorphisms of inducible nitric oxide synthase (NOS2) gene is related to fractional exhaled nitric oxide (FeNO) level in steroid-naive patients with asthma, but its association with treatment outcomes remains unclear. Thus, in this study, we aimed to clarify the association of NOS2 polymorphism with exacerbations in patients with asthma.

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Why is it important?

We observed an association of NOS2 pentanucleotide repeat polymorphism with changing NOS2 mRNA expression levels, which were highest in subjects having ≤11 allele repetitions of CCTTT polymorphism, whereas there were no significant differences in FeNO levels and NOx concentrations between the genotype groups. Moreover, our results suggested that having allele ≤11 repeats contributes to increasing the risk of exacerbation in patients with moderate to severe asthma.