What is it about?
Fullerenol C60(OH)24 nanoparticles (FNP) are promising radioprotectors in prevention of early and late ionizing radiation injury. The aim of this studywas to compare the efficacy of FNP and amifostine (AMI) in protection of rats exposed to whole-body X-ray irradiation (7 or 8 Gy). Both compounds (FNP, 100 mg/kg ip; AMI, 300 mg/kg ip) were given 30 min before irradiation throughout the study. The general radioprotective efficacy of FNP and AMI were evaluated in rats irradiated with an absolutely lethal dose of X-rays (8 Gy) and their survival were monitored during the period of 30 days after irradiation. Both compounds were of comparable efficacy. Tissue-protective effects of tested compounds were assessed in rats irradiated with an sublethal dose of X-rays (7 Gy). For this purpose, the animals were sacrificed on the 7th and 28th day after irradiation. Their lung, heart, liver, kidney, small intestine and spleen were taken for histopathological and semiquantitative analysis. Careful examination of established tissue and vascular alteration revealed better radioprotective effects of FNP compared to those of AMI on the small intestine, lung and spleen, while AMI had better radioprotective effects than FNP in protection of the heart, liver and kidney. Results of this study confirmed high radioprotective efficacy of FNP in irradiated rats that was comparable to that of AMI, a well-known radioprotector.
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Why is it important?
the aim of this study was to thoroughly compare the efficacy of FNP and AMI in protection of various tissues in irradiated rats.
Perspectives
Our results have indicated that FNP (100 mg/kg) expressed better radioprotection of the small intestine, lung and spleen, while these effects of AMI (300 mg/kg) were more prominent in the heart, liver and kidney. FNP examined in this model by comparing with AMI, potent cytoprotector with antiinflamatory effects, is potentially a valuable candidate for further investigation as an agent for the prevention and/or treatment of various disorders associated with inflammation.
Research Professor Vesna Jaćević
National Poison Control Centre, Military Medical Academy & Medical Faculty, University of Defence, Belgrade, Sebia
Read the Original
This page is a summary of: Effects of fullerenol nanoparticles and amifostine on radiation-induced tissue damages: Histopathological analysis, Journal of Applied Biomedicine, November 2016, Elsevier,
DOI: 10.1016/j.jab.2016.05.004.
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