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A subtype of melanoma carries particularly large amounts of UV-induced mutations. This seems to increase the response rates of anti PD1 therapy.

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This page is a summary of: Tumor mutational burden and response to PD-1 inhibitors in a case series of patients with metastatic desmoplastic melanoma, Journal of the American Academy of Dermatology, December 2018, Elsevier,
DOI: 10.1016/j.jaad.2018.12.020.
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