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Sepsis-associated encephalopathy (SAE) is caused by neuroinflammation, in which microglia play a central role by releasing proinflammatry factors. Microglia express dopamine D1-like receptors that mediate elevation of intracellular cAMP level. As a result, a BBB-permeable selective D1-like receptor agonist ameliorated SAE symptoms by suppressing proinflammatory activation of microglia in a mouse sepsis model brain.
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This page is a summary of: A dopamine D1-like receptor-specific agonist improves the survival of septic mice, iScience, April 2024, Elsevier,
DOI: 10.1016/j.isci.2024.109587.
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