What is it about?
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years.
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Why is it important?
The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resistance to its other analogues have decreased their consumption in many geographical areas.
Perspectives
The significance of the quinoline ring at quinoline-based antimalarial drugs has prompted research centers and pharmaceutical companies to focus on the design and synthesis of new analogues of these drugs, especially CQ and AQ analogues.
Dr Andre S Pimentel
Pontificia Universidade Catolica do Rio de Janeiro
Read the Original
This page is a summary of: Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity, International Journal for Parasitology Drugs and Drug Resistance, December 2018, Elsevier,
DOI: 10.1016/j.ijpddr.2018.10.002.
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