What is it about?
Recent data from absence epileptic patients and animal models provide evidence for significant impairments of attention, memory, and psychosocial functioning. Here, we outline aspects of the electrophysiological and structural background of these dysfunctions by investigating changes in hippocampal and cortical GABAergic inhibitory interneurons in two genetically absence epileptic rat strains: the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and the Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats.
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Why is it important?
Our results suggest an enhanced synchronization and functional connections between the hippocampus and S1 cortex as well as thalamocortical activities during SWDs and a functional alteration of inhibitory mechanisms in the hippocampus and S1 cortex of two genetic models of absence epilepsy, presumably in relation with increased neuronal activity and seizure-induced neuronal injury.
Perspectives
The novel electrophysiological and neuroanatomical findings provided here lay out multiple avenues for future experiments aiming at investigating the association between our results and impaired learning and memory performance in the GAERS and WAG/Rij rat strains.
Dr Zsolt Kovacs
Eötvös Loránd University
Read the Original
This page is a summary of: Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy, Epilepsy Research, September 2018, Elsevier,
DOI: 10.1016/j.eplepsyres.2018.05.013.
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