Embelin lipid nanospheres; in vivo evaluation for enhanced treatment of ulcerative colitis

What is it about?

Embelin lipid nanospheres, developed using soya bean oil/virgin coconut oil as liquid lipid carrier and soya/egg lecithin as stabilizer by hot homogenization followed by ultrasonication technique, showed enhanced treatment in Ulcerative colitis when compared to Conventional embelin.

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Why is it important?

Conventional treatment of ulcerative colitis requires the frequent administration of anti-inflammatory drugs at high doses, which leads serious adverse effects such as diarrhoea. In case of IBD treatment, reduction of drug carrier size has been recognized an efficient way to prolong colonic passage time. It has been reported that by reducing the size of a formulation, the residence time in the large intestine can be improved and this also holds true for patients suffering from diarrhoea. Plant remedies play a significant role in the treatment of many inflammatory disease conditions of IBD.