What is it about?
We tested chloramphenicol + fosfomycin (CAF+FOS) against 10 VREfm isolated from blood. MICs were 64 to 512 mg/mL for fosfomycin and 8 to 16 mg/mL for chloramphenicol. The combination decreased both MICs, with a synergic effect in 50% of the isolates and an additive effect in the remaining 50%.
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Why is it important?
It supports the combination of fosfomycin and chloramphenicol against VRE
Perspectives
This combination therapy should be considered when daptomycin or linezolid are not viable options
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: Synergistic activity of fosfomycin and chloramphenicol against vancomycin-resistant Enterococcus faecium (VREfm) isolates from bloodstream infections, Diagnostic Microbiology and Infectious Disease, October 2020, Elsevier,
DOI: 10.1016/j.diagmicrobio.2020.115241.
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