What is it about?
Blood clotting is regulated with the size of tiny organelles in the cells of the blood vessel. We showed here, that its size is not random, but grows in units depending on the size of the cellular factory where it is generated.
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Why is it important?
Healthy blood clotting is vitally important. Defective clotting can lead bleeding to death in an injury, superfluous clotting is fatal because of thrombosis. Therefore, it is very useful that this method allows to test the blood clotting side effect of any medicine.
Perspectives
We developed a novel and powerful image processing-based measuring method. Using this method we can easily measure the length of millions of tiny organelles in the blood vessel cells. This is very helpful to study the blood clotting effects of thousands of medicines.
Dr Janos KristonVizi
University College London
Read the Original
This page is a summary of: A Two-Tier Golgi-Based Control of Organelle Size Underpins the Functional Plasticity of Endothelial Cells, Developmental Cell, May 2014, Elsevier,
DOI: 10.1016/j.devcel.2014.03.021.
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